Phenotypes Associated with This Genotype

Genotype
MGI:3487264

• Allelic Composition: Ret^{tm3.1(RET)Jmi}/Ret⁺
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:93262 )

• died with the first 4 weeks of life

digestive/alimentary system

abnormal colon morphology ( J:93262 )

• narrowed distal colon

• dilated proximal colon

distended ileum ( J:93262 )

• dilated

endocrine/exocrine glands

seminiferous tubule degeneration ( J:93262 )

♂ • by 4 weeks of age

renal/urinary system

kidney cyst ( J:93262 )

• 50% with renal tubular cysts and proteinaceous casts at 3, 4 weeks of age

decreased renal glomerulus number ( J:93262 )

abnormal kidney development ( J:93262 )

• development variable from normal to bilateral kidney agenesis

• hypoplastic with 50% reduction in glomeruli but normal kidney organization

renal hypoplasia ( J:93262 )

• hypoplastic with 50% reduction in glomeruli but normal kidney organization

renal cast ( J:93262 )

• 50% with renal tubular cysts and proteinaceous casts at 3, 4 weeks of age

reproductive system

seminiferous tubule degeneration ( J:93262 )

♂ • by 4 weeks of age

abnormal spermatogenesis ( J:93262 )

♂ • fewer proliferating cells in the testis at day 10 when cells first enter meiosis

♂ • spermiogenesis at 4 weeks of age

arrest of spermatogenesis ( J:93262 )

♂ • maturation arrested

♂ • fewer round spermatids and no elongated ones

nervous system

abnormal enteric nervous system morphology ( J:93262 )

• reductions in neuron numbers and neuronal fiber density in the proximal small intestine

abnormal enteric ganglia morphology ( J:93262 )

• intestinal aganglionosis involving distal colon and ileocecal junction

abnormal pterygopalatine ganglion morphology ( J:93262 )

• 50% reduced neuron number in sphenopalatine ganglia

growth/size/body

kidney cyst ( J:93262 )

• 50% with renal tubular cysts and proteinaceous casts at 3, 4 weeks of age