Analysis Tools
mortality/aging
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• embryos die between E10.5 - E12.5
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cardiovascular system
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• atrial hyperplasia with an outgrowth of cells into the common atrial chamber is seen at E9.5 in 25% of embryos
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• at E10.5 ventricular hypoplasia with defective trabeculae and myocardia is seen in 36% of embryos
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• at E10.5 ventricular hypoplasia with defective trabeculae and myocardia is seen in 36% of embryos
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hemorrhage
(
J:93191
)
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• hemorrhaging in the body or head is seen in some embryos at E9.5
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• a blood filled pericardium is seen in some embryos at E9.5
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cellular
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• MEFs show partial loss of contact inhibition, increased retention of cytoplasmic bridges between neighboring cells, and increased growth in later passages
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• BrdU incorporation is decreased in the embryonic conceptus but not extraembryonic tissues in 75% of embryos at E9.5 and decreased or absent in all live embryos at E10.5
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• both MEFs and embryonic cells have more cells with multiple centrosomes and more cells with abnormal chromosome numbers
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embryo
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• embryos are smaller or developmentally delayed at E9.5
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• an irregular kinked neural tube is seen in some embryos at E9.5
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muscle
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• at E10.5 ventricular hypoplasia with defective trabeculae and myocardia is seen in 36% of embryos
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nervous system
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• an irregular kinked neural tube is seen in some embryos at E9.5
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growth/size/body
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• embryos are smaller or developmentally delayed at E9.5
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homeostasis/metabolism
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• a blood filled pericardium is seen in some embryos at E9.5
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