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Phenotypes Associated with This Genotype
Genotype
MGI:3056607
Allelic
Composition
Lats2tm1Raz/Lats2tm1Raz
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lats2tm1Raz mutation (0 available); any Lats2 mutation (9 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

cardiovascular system
• at E10.5 ventricular hypoplasia with defective trabeculae and myocardia is seen in 36% of embryos
• atrial hyperplasia with an outgrowth of cells into the common atrial chamber is seen at E9.5 in 25% of embryos
• at E10.5 ventricular hypoplasia with defective trabeculae and myocardia is seen in 36% of embryos
• hemorrhaging in the body or head is seen in some embryos at E9.5
• a blood filled pericardium is seen in some embryos at E9.5

cellular
• MEFs show partial loss of contact inhibition, increased retention of cytoplasmic bridges between neighboring cells, and increased growth in later passages
• BrdU incorporation is decreased in the embryonic conceptus but not extraembryonic tissues in 75% of embryos at E9.5 and decreased or absent in all live embryos at E10.5
• both MEFs and embryonic cells have more cells with multiple centrosomes and more cells with abnormal chromosome numbers

embryo
• embryos are smaller or developmentally delayed at E9.5
• an irregular kinked neural tube is seen in some embryos at E9.5

muscle
• at E10.5 ventricular hypoplasia with defective trabeculae and myocardia is seen in 36% of embryos

nervous system
• an irregular kinked neural tube is seen in some embryos at E9.5

growth/size/body
• embryos are smaller or developmentally delayed at E9.5

homeostasis/metabolism
• a blood filled pericardium is seen in some embryos at E9.5


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory