Phenotypes Associated with This Genotype

Genotype
MGI:3056133

• Allelic Composition: Sirpa^tm1Nog/Sirpa^tm1Nog
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Presence of megakaryocytes in the spleen of 11 week old Sirpa^tm1Nog/Sirpa^tm1Nog mice

growth/size/body

decreased body weight ( J:79592 )

• mean body mass is reduced by about 10% compared to wild-type

hematopoietic system

increased megakaryocyte cell number ( J:79592 )

• an increased number of megakaryocytes are seen in the spleen at 11 weeks of age

thrombocytopenia ( J:79592 )

• the circulating platelet count is reduced by about 25% compared to wild-type mice

• the life span of platelets is significantly decreased in mutants

decreased T cell number ( J:79592 )

• the proportion of CD4+ and CD8+ cells are decreased compared to wild-type mice

abnormal macrophage physiology ( J:79592 )

• the phagocytic activity of peritoneal macrophages is significantly enhanced

immune system

decreased T cell number ( J:79592 )

• the proportion of CD4+ and CD8+ cells are decreased compared to wild-type mice

abnormal macrophage physiology ( J:79592 )

• the phagocytic activity of peritoneal macrophages is significantly enhanced

abnormal Langerhans cell physiology ( J:88694 )

• 2,4-dinitro-1-fluorobenzene-induced migration of Langerhans cells out of the epidermis is significantly impaired

liver/biliary system

hepatic steatosis ( J:79592 )