Analysis Tools
mortality/aging
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• mutants are born alive but die within the first day
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nervous system
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• at E14.5, large numbers of apoptotic cells can be seen in the cre-expressing neuronal layer, in contrast no apoptotic cells are seen in controls
• at E16.5, the cortex is filled with many apoptotic cells and at E18.5 the cortex is highly degenerated and thin with abnormal layering and a wavelike structure
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