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Phenotypes Associated with This Genotype
Genotype
MGI:3055194
Allelic
Composition
Rasgrp2tm1Amg/Rasgrp2tm1Amg
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rasgrp2tm1Amg mutation (0 available); any Rasgrp2 mutation (36 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• neutrophils from homozygous mutant mice exhibit strong defects in Rap1 and beta1 and beta2 integrin activation while maintaining normal calcium flux, degranulation, and ROS generation
• neutrophils from homozygous mutant mice failed to adhere firmly to stimulated venules and to migrate into sites of inflammation
• platelets are unable to form stable thrombi when stimulated by collagen under flow conditions and mutants are resistant to collagen-induced thrombi mediated mortali
• aggregation of platelets in response to calcium ionophore, collagen, ADP and a thromboxane A analog is impaired (J:92864)
• deficiency caused complete inhibition of arterial thrombus formation in mice (J:122618)

immune system
• neutrophils from homozygous mutant mice exhibit strong defects in Rap1 and beta1 and beta2 integrin activation while maintaining normal calcium flux, degranulation, and ROS generation
• neutrophils from homozygous mutant mice failed to adhere firmly to stimulated venules and to migrate into sites of inflammation

homeostasis/metabolism
• platelets are unable to form stable thrombi when stimulated by collagen under flow conditions and mutants are resistant to collagen-induced thrombi mediated mortali
• aggregation of platelets in response to calcium ionophore, collagen, ADP and a thromboxane A analog is impaired (J:92864)
• deficiency caused complete inhibition of arterial thrombus formation in mice (J:122618)
• after tail transection mutants bleed for at least 30 minutes compared to less than 8 minutes for wild-type mice
• mutants do not develop spontaneous hemorrhage or anemia

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
leukocyte adhesion deficiency 3 DOID:0110912 OMIM:612840
J:122618


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/23/2022
MGI 6.20
The Jackson Laboratory