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Phenotypes Associated with This Genotype
Genotype
MGI:3055138
Allelic
Composition		 Cd22tm1Tft/Cd22tm1Tft
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd22tm1Tft mutation (0 available); any Cd22 mutation (62 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
increased B cell proliferation ( J:92736 )
• B cell turnover is increased in all tissues
decreased B cell number ( J:92736 )
• the percentage of mature recirculating B cells, B cells in the blood, and marginal zone B cells are reduced however the number of B cells in the lymph nodes is increased

immune system
increased B cell proliferation ( J:92736 )
• B cell turnover is increased in all tissues
decreased B cell number ( J:92736 )
• the percentage of mature recirculating B cells, B cells in the blood, and marginal zone B cells are reduced however the number of B cells in the lymph nodes is increased

cellular
increased B cell proliferation ( J:92736 )
• B cell turnover is increased in all tissues

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory