Phenotypes Associated with This Genotype

Genotype
MGI:3055108

• Allelic Composition: Casp8^tm1Wll/Casp8^tm1.1Yuan; Tg(Tie1-cre)9Ref/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * MF1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:92722 )

• compound heterozygotes die around E12, similar to Casp8^tm1.1Yuan homozygotes

cardiovascular system

abnormal vitelline vasculature morphology ( J:92722 )

• the density of the vasculature in the yolk sac is decreased

visceral vascular congestion ( J:92722 )

• severe congestion of the liver and large vessels of the chest and abdomen similar to Casp8^tm1.1Yuan homozygotes is seen

myocardium necrosis ( J:92722 )

• extensive necrosis of the cardiomyocytes in the ventricles and atria is seen

globular heart ( J:92722 )

• the heart has a globose shape

thin ventricular wall ( J:92722 )

• around E12 thin and occasionally ruptured ventricular walls are seen

• heart defects are not seen in mutants at E10-E11.5

pericardial edema ( J:92722 )

• around E12, the pericardial space is enlarged consistent with pericardial edema

muscle

myocardium necrosis ( J:92722 )

• extensive necrosis of the cardiomyocytes in the ventricles and atria is seen

embryo

abnormal vitelline vasculature morphology ( J:92722 )

• the density of the vasculature in the yolk sac is decreased

wavy neural tube ( J:92722 )

• an undulated neural tube is seen

abnormal visceral yolk sac morphology ( J:92722 )

• the density of the vasculature and amount of blood in the yolk sac is decreased

• increased cell death is seen in the yolk sac at E10.5 even when no signs of vascular degeneration were detected

hematopoietic system

hematopoietic system phenotype ( J:92722 )

N • hematopoietic progenitor numbers are not decreased unlike in Casp8^tm1.1Yuan homozygotes

homeostasis/metabolism

pericardial edema ( J:92722 )

• around E12, the pericardial space is enlarged consistent with pericardial edema

nervous system

wavy neural tube ( J:92722 )

• an undulated neural tube is seen