Phenotypes Associated with This Genotype

Genotype
MGI:3054987

• Allelic Composition: Ctnnb1^tm2Kem/Ctnnb1^tm2Kem; Emx1^tm1(cre)Yql/Emx1⁺
• Genetic Background: B6.129-Emx1^tm1(cre)Yql Ctnnb1^tm2Kem

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal nursing ( J:92923 )

♀ • females display poor nursing behavior

♀ • 80% do not nurse at all and abandon pups

seizures ( J:92923 )

• seizures can be induced by handling in 4 month old animals

increased susceptibility to pharmacologically induced seizures ( J:92923 )

• increased sensitivity to PTZ induced seizures

• 83% die within 60 minutes of PTZ injection compared to 58% mortality in controls

• significantly higher numbers of phase I and phase II seizures

• duration of seizures increased for phase I

• 2X as much time in seizure as controls

growth/size/body

decreased body size ( J:92923 )

• males significantly smaller than littermates

reproductive system

male infertility ( J:92923 )

♂

nervous system

seizures ( J:92923 )

• seizures can be induced by handling in 4 month old animals

increased susceptibility to pharmacologically induced seizures ( J:92923 )

• increased sensitivity to PTZ induced seizures

• 83% die within 60 minutes of PTZ injection compared to 58% mortality in controls

• significantly higher numbers of phase I and phase II seizures

• duration of seizures increased for phase I

• 2X as much time in seizure as controls

dilated lateral ventricle ( J:92923 )

• as a result of missing hippocampal structures

absent corpus callosum ( J:92923 )

absent hippocampal commissure ( J:92923 )

• lack hippocampal commissure

abnormal hippocampus morphology ( J:92923 )

• CA1, CA2, CA3 all not detected

absent hippocampus CA1 region ( J:92923 )

absent hippocampus CA2 region ( J:92923 )

absent hippocampus CA3 region ( J:92923 )

absent dentate gyrus ( J:92923 )

abnormal cerebral cortex morphology ( J:92923 )

• impaired cortical development, failure of lobes to extend caudally

• adult brain similar in appearance to perinatal brain

thin cerebral cortex ( J:92923 )

• thinner cortex