About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:3054986
Allelic
Composition		 Rxfp1tm1Aia/Rxfp1tm1Aia
Tg(Ins2-Insl3)4Imad/0
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rxfp1tm1Aia mutation (0 available); any Rxfp1 mutation (53 available)
Tg(Ins2-Insl3)4Imad mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
decreased nipple size ( J:92627 )
• mutant females have small nipples
ectopic ovary ( J:92627 )
• the ovaries descend into a low intra-abdominal position similar to Tg(Ins2-Insl3)4Imad hemizygotes
abnormal lactation ( J:92627 )
• about 2/3 of the mutant females are unable to nurse pups

reproductive system
ectopic ovary ( J:92627 )
• the ovaries descend into a low intra-abdominal position similar to Tg(Ins2-Insl3)4Imad hemizygotes
abnormal gubernaculum morphology ( J:92627 )
• abnormal development of the gubernaculum results in descent of the ovaries similar to Tg(Ins2-Insl3)4Imad hemizygotes

integument
decreased nipple size ( J:92627 )
• mutant females have small nipples
abnormal lactation ( J:92627 )
• about 2/3 of the mutant females are unable to nurse pups

skeleton
abnormal gubernaculum morphology ( J:92627 )
• abnormal development of the gubernaculum results in descent of the ovaries similar to Tg(Ins2-Insl3)4Imad hemizygotes

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory