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Phenotypes Associated with This Genotype
Genotype
MGI:3054063
Allelic
Composition
Edn1tm1Ywa/Edn1tm1Ywa
Tg(AQP2-cre)2Dek/0
Genetic
Background
involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Edn1tm1Ywa mutation (1 available); any Edn1 mutation (24 available)
Tg(AQP2-cre)2Dek mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• mutants are hypertensive compared to littermates that do not express cre
• on a high salt diet systolic blood pressure rises in mutants but not littermate control

renal/urinary system
• on a high salt diet decreased Na excretion is seen for the first 3 days in mutants compared to littermate controls

homeostasis/metabolism
• on a high salt diet decreased Na excretion is seen for the first 3 days in mutants compared to littermate controls


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/25/2025
MGI 6.24
The Jackson Laboratory