Phenotypes for Fas Tnfrsf1a MGI:3053737 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Fas^lpr/Fas^lpr Tnfrsf1a^tm1.1Gkl/Tnfrsf1a^tm1.1Gkl
Genetic Background	involves: 129/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fas^lpr mutation (39 available); any Fas mutation (83 available)
Tnfrsf1a^tm1.1Gkl mutation (0 available); any Tnfrsf1a mutation (49 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

liver inflammation ( J:92470 )

• liver inflammation is seen by 3-4 weeks of age and persists throughout adulthood

• no change in the severity of liver inflammation is seen compared to Tnfrsf1a^tm1Gkl in homozygotes

liver/biliary system

liver inflammation ( J:92470 )

• liver inflammation is seen by 3-4 weeks of age and persists throughout adulthood

• no change in the severity of liver inflammation is seen compared to Tnfrsf1a^tm1Gkl in homozygotes

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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