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Phenotypes Associated with This Genotype
Genotype
MGI:3053442
Allelic
Composition		 Tnfrsf1atm1Mak/Tnfrsf1atm1Mak
Genetic
Background		 involves: 129S2/SvPas * C57BL/6J * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnfrsf1atm1Mak mutation (2 available); any Tnfrsf1a mutation (48 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
granulomatous inflammation ( J:55889 )
• in response to infection with Mycobacterium avium, mice developed extensive tissue necrosis in all infected tissues and persistent granulomatous lesions which went through acute disintegration before death
• mice depleted of either CD4+ or CD8+ cells after granuloma initiation stayed healthy to day 38 postinfection, with no signs of granuloma destruction

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/28/2024
MGI 6.13 		The Jackson Laboratory