Phenotypes Associated with This Genotype

Genotype
MGI:3053046

• Allelic Composition: Nfkbia^tm1Bal/Nfkbia^tm1Bal; Nfkbie^tm1Syme/Nfkbie^tm1Syme
• Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:88142 )

• double homozygotes are born alive but remain cyanotic and die within 10-30 minutes

hematopoietic system

increased B cell apoptosis ( J:88142 )

• increased among B cells

increased T cell apoptosis ( J:88142 )

• increased among T cells in transition from double positive to single positive

abnormal B cell differentiation ( J:88142 )

• decreased numbers of B cell precursors

decreased immature B cell number ( J:88142 )

• very low numbers of immature B cells

abnormal T cell differentiation ( J:88142 )

• development from the double positive stage to the single positive stage is reduced

decreased pre-B cell number ( J:88142 )

• clear reduction of B220+CD43- cells

immune system

increased B cell apoptosis ( J:88142 )

• increased among B cells

increased T cell apoptosis ( J:88142 )

• increased among T cells in transition from double positive to single positive

abnormal B cell differentiation ( J:88142 )

• decreased numbers of B cell precursors

decreased immature B cell number ( J:88142 )

• very low numbers of immature B cells

abnormal T cell differentiation ( J:88142 )

• development from the double positive stage to the single positive stage is reduced

decreased pre-B cell number ( J:88142 )

• clear reduction of B220+CD43- cells

cellular

increased B cell apoptosis ( J:88142 )

• increased among B cells

increased T cell apoptosis ( J:88142 )

• increased among T cells in transition from double positive to single positive