Nfkbia^tm1Bal
Targeted Allele Detail

Summary

• Symbol: Nfkbia^tm1Bal
• Name: nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha; targeted mutation 1, David Baltimore
• MGI ID: MGI:1858084
• Synonyms: IkappaBalpha^-
• Gene: Nfkbia Location: Chr12:55536195-55539432 bp, - strand Genetic Position: Chr12, 24.0 cM, cytoband C1-C3
• Alliance: Nfkbia^tm1Bal page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:30058
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The lacZ gene was inserted in frame 13 nucleotides downstream of the translational start site followed by a PGK-neomycin gene in reverse orientation thus replacing the remainder of the gene. Absence of protein product was established by Western blot analysis. (J:30058)

Expression

In Mice Carrying this Mutation:	12 assay results
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Nfkbia Mutation: 19 strains or lines available

References

• Original: J:30058 Beg AA, et al., Constitutive NF-kappa B activation, enhanced granulopoiesis, and neonatal lethality in I kappa B alpha-deficient mice. Genes Dev. 1995 Nov 15;9(22):2736-46
• All: 11 reference(s)