Phenotypes Associated with This Genotype

Genotype
MGI:3052168

• Allelic Composition: Ntrk1^{tm2(Ntrk3)Apat}/Ntrk1^{tm2(Ntrk3)Apat}
• Genetic Background: involves: 129S1/Sv

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:92099 )

• homozygotes die before reaching adulthood

behavior/neurological

abnormal pain threshold ( J:92099 )

• homozygotes do not respond to painful stimuli at birth

nervous system

increased muscle spindle number ( J:92099 )

• as a result of the increase in proprioceptive neurons the number of muscle spindles is increased 2 - 3 fold in some muscle groups

decreased sensory neuron number ( J:92099 )

• the overall number of sensory neurons is decreased however the number of proprioceptive neurons is increased compared to Ntrk1^tm1Apat homozygotes

abnormal proprioceptive neuron morphology ( J:92099 )

• the overall number of sensory neurons is decreased however the number of proprioceptive neurons is increased compared to Ntrk1^tm1Apat homozygotes

muscle

increased muscle spindle number ( J:92099 )

• as a result of the increase in proprioceptive neurons the number of muscle spindles is increased 2 - 3 fold in some muscle groups