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Phenotypes Associated with This Genotype
Genotype
MGI:3052052
Allelic
Composition		 Cd8atm1Mak/Cd8atm1Mak
Genetic
Background		 SJL.129S2(B6)-Cd8atm1Mak/Rdgz
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd8atm1Mak mutation (7 available); any Cd8a mutation (37 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased susceptibility to Picornaviridae infection ( J:92227 )
• inflammation persists in the susceptible SJL/J background

nervous system
demyelination ( J:92227 )
• demyelination was severe on both the susceptible PL/J and SJL/J backgrounds after infection with TMEV

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory