Phenotypes Associated with This Genotype

Genotype
MGI:3051965

• Allelic Composition: Cd19^tm1(cre)Cgn/Cd19⁺; Tgfbr2^tm1Roes/Tgfbr2^tm1Roes
• Genetic Background: involves: 129P2/OlaHsd * BALB/c

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

absent plasma cells ( J:90558 )

• IgA expressing plasma cells are virtually absent from the spleen and bone marrow of mutants

increased leukocyte cell number ( J:90558 )

• a 3 fold increase in leukocyte numbers is seen

abnormal B-1 B cell morphology ( J:90558 )

abnormal B-1 B cell number ( J:90558 )

• increased proliferation of mature splenic B cells is seen, however a decrease in B-1 cell proliferation and increase in B-1 cell survival time are also seen

abnormal B cell physiology ( J:90558 )

• more activated B cells are found in mutants

• sera from 9 week or 8 month old mutants shows increased binding to double stranded DNA indicating impaired control of B cell activation

decreased IgA level ( J:90558 )

• serum IgA levels are reduced by about 10 fold and are not increased in response to antigens

increased IgG level ( J:90558 )

• serum levels of all IgG subclasses are increased with IgG1 showing the largest increase (16 fold)

• IgG3 antigen-induced expression is greatly increased

increased IgM level ( J:90558 )

• serum IgM levels and IgM expression by peripheral B cells are increased

immune system

enlarged Peyer's patches ( J:90558 )

• Peyer's patches are larger and more distinct

absent plasma cells ( J:90558 )

• IgA expressing plasma cells are virtually absent from the spleen and bone marrow of mutants

increased leukocyte cell number ( J:90558 )

• a 3 fold increase in leukocyte numbers is seen

abnormal B-1 B cell morphology ( J:90558 )

abnormal B-1 B cell number ( J:90558 )

• increased proliferation of mature splenic B cells is seen, however a decrease in B-1 cell proliferation and increase in B-1 cell survival time are also seen

abnormal B cell physiology ( J:90558 )

• more activated B cells are found in mutants

• sera from 9 week or 8 month old mutants shows increased binding to double stranded DNA indicating impaired control of B cell activation

decreased IgA level ( J:90558 )

• serum IgA levels are reduced by about 10 fold and are not increased in response to antigens

increased IgG level ( J:90558 )

• serum levels of all IgG subclasses are increased with IgG1 showing the largest increase (16 fold)

• IgG3 antigen-induced expression is greatly increased

increased IgM level ( J:90558 )

• serum IgM levels and IgM expression by peripheral B cells are increased

digestive/alimentary system

enlarged Peyer's patches ( J:90558 )

• Peyer's patches are larger and more distinct