Phenotypes Associated with This Genotype

Genotype
MGI:3051611

• Allelic Composition: Btn1a1^tm1Ihm/Btn1a1^tm1Ihm
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

abnormal mammary gland morphology ( J:91440 )

♀ • secretory cells contain large lipid droplets which may break through holes in the apical surface filling the luminal spaces

abnormal lactation ( J:91440 )

♀ • lactation is compromised with only 50 - 60% of pups surviving to weaning

abnormal milk composition ( J:91440 )

♀ • milk contains 25-35% (wt/vol) lipid, a 50% increase compared to wild-type mice

♀ • many large lipid droplets are seen in the milk from homozygous mutants

integument

abnormal mammary gland morphology ( J:91440 )

♀ • secretory cells contain large lipid droplets which may break through holes in the apical surface filling the luminal spaces

abnormal lactation ( J:91440 )

♀ • lactation is compromised with only 50 - 60% of pups surviving to weaning

abnormal milk composition ( J:91440 )

♀ • milk contains 25-35% (wt/vol) lipid, a 50% increase compared to wild-type mice

♀ • many large lipid droplets are seen in the milk from homozygous mutants