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Phenotypes Associated with This Genotype
Genotype
MGI:3051611
Allelic
Composition
Btn1a1tm1Ihm/Btn1a1tm1Ihm
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Btn1a1tm1Ihm mutation (0 available); any Btn1a1 mutation (32 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• secretory cells contain large lipid droplets which may break through holes in the apical surface filling the luminal spaces
• lactation is compromised with only 50 - 60% of pups surviving to weaning
• milk contains 25-35% (wt/vol) lipid, a 50% increase compared to wild-type mice
• many large lipid droplets are seen in the milk from homozygous mutants

integument
• secretory cells contain large lipid droplets which may break through holes in the apical surface filling the luminal spaces
• lactation is compromised with only 50 - 60% of pups surviving to weaning
• milk contains 25-35% (wt/vol) lipid, a 50% increase compared to wild-type mice
• many large lipid droplets are seen in the milk from homozygous mutants


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/22/2024
MGI 6.24
The Jackson Laboratory