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Phenotypes Associated with This Genotype
Genotype
MGI:3051599
Allelic
Composition		 Agtr1atm1Unc/Agtr1atm1Unc
Hprt1tm1(Ggt1-Agtr1)Cof/Y
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Agtr1atm1Unc mutation (1 available); any Agtr1a mutation (38 available)
Hprt1tm1(Ggt1-Agtr1)Cof mutation (0 available); any Hprt1 mutation (1280 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
hypotension ( J:91837 )
• hypotension develops on low salt diet and blood pressure fails to rise on a high salt diet
• fails to correct blood pressure defect caused by homozygous Agtr1tm1Unc

homeostasis/metabolism
decreased urine osmolality ( J:91837 )
• fails to correct defect in urinary concentration caused by homozygous Agtr1tm1Unc

renal/urinary system
decreased urine osmolality ( J:91837 )
• fails to correct defect in urinary concentration caused by homozygous Agtr1tm1Unc

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory