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Phenotypes Associated with This Genotype
Genotype
MGI:3051589
Allelic
Composition
Ghrhtm1Salv/Ghrhtm1Salv
Genetic
Background
involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ghrhtm1Salv mutation (1 available); any Ghrh mutation (14 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands

growth/size/body
• by 8 weeks of age body weight was 55-60% of controls
• body length about 3/4 that of controls
• homozygotes from heterozygous mothers showed slower growth rates
• slightly smaller than controls at 2 weeks of age
• significantly smaller than controls at 3 weeks of age
• only 55-60% of control body weight by 8 weeks of age

liver/biliary system
• IGF-I production reduced

reproductive system
• females produced smaller than normal litters
• 8.5% mortality of pups in first 24 hours
• normal maternal behavior in spite of failure to thrive observed in mice born from primiparous mothers

homeostasis/metabolism
• pituitary growth hormone levels about 1/5 normal

nervous system

immune system

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
isolated growth hormone deficiency type IA DOID:0060873 OMIM:262400
J:91828


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory