Phenotypes Associated with This Genotype

Genotype
MGI:3051136

• Allelic Composition: Nfat5^tm1Snh/Nfat5⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

decreased T cell proliferation ( J:91482 )

• proliferation of T cells is reduced in hypertonic and hyperosmotic conditions but not in isosmotic or isotonic conditions

thymus hypoplasia ( J:91482 )

• thymus cellularity is reduced by 40% compared to wild-type littermates

spleen hypoplasia ( J:91482 )

• spleen cellularity is reduced by 32% compared to wild-type littermates

abnormal immunoglobulin level ( J:91482 )

• antigen specific antibody production is reduced 44% compared to wild-type mice

decreased IgG level ( J:91482 )

• total serum IgG but not IgM levels are reduced by 35%

immune system

decreased T cell proliferation ( J:91482 )

• proliferation of T cells is reduced in hypertonic and hyperosmotic conditions but not in isosmotic or isotonic conditions

thymus hypoplasia ( J:91482 )

• thymus cellularity is reduced by 40% compared to wild-type littermates

spleen hypoplasia ( J:91482 )

• spleen cellularity is reduced by 32% compared to wild-type littermates

abnormal immunoglobulin level ( J:91482 )

• antigen specific antibody production is reduced 44% compared to wild-type mice

decreased IgG level ( J:91482 )

• total serum IgG but not IgM levels are reduced by 35%

endocrine/exocrine glands

thymus hypoplasia ( J:91482 )

• thymus cellularity is reduced by 40% compared to wild-type littermates

cellular

decreased T cell proliferation ( J:91482 )

• proliferation of T cells is reduced in hypertonic and hyperosmotic conditions but not in isosmotic or isotonic conditions