Phenotypes for Nfat5 MGI:3051135 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Nfat5^tm1Snh/Nfat5^tm1Snh
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

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Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nfat5^tm1Snh mutation (0 available); any Nfat5 mutation (68 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:91482 )

• Background Sensitivity: with fewer than two generations of backcrossing to C57BL/6, embryos begin to die around E14.5

perinatal lethality, complete penetrance ( J:91482 )

• after more than 3 generations of backcrossing to C57BL/6, homozygous embryos are present at the expected frequency through E20.5 but die in the immediate perinatal period

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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