Phenotypes Associated with This Genotype

Genotype
MGI:3050585

• Allelic Composition: Alx1^tm1Crm/Alx1^tm1Crm; Alx4^tm1Rwi/Alx4⁺
• Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

craniofacial

abnormal basisphenoid bone morphology ( J:51128 )

short mandible ( J:51128 )

• mandibular reduction is mainly restricted to the region anterior to the alveolar process that surrounds the molars

abnormal nasal septum cartilage morphology ( J:51128 )

• mutants that carry three mutant alleles in any combination show cleft face associated with failure to fuse the cartilages of the nasal septum

midline facial cleft ( J:51128 )

• mutant mice show a midline fusion defect that results in cleft face

respiratory system

abnormal nasal septum cartilage morphology ( J:51128 )

• mutants that carry three mutant alleles in any combination show cleft face associated with failure to fuse the cartilages of the nasal septum

skeleton

abnormal basisphenoid bone morphology ( J:51128 )

short mandible ( J:51128 )

• mandibular reduction is mainly restricted to the region anterior to the alveolar process that surrounds the molars

abnormal nasal septum cartilage morphology ( J:51128 )

• mutants that carry three mutant alleles in any combination show cleft face associated with failure to fuse the cartilages of the nasal septum

nervous system

exencephaly ( J:51128 )

• all double homozygous null mice display exencephaly

growth/size/body

short mandible ( J:51128 )

• mandibular reduction is mainly restricted to the region anterior to the alveolar process that surrounds the molars

abnormal nasal septum cartilage morphology ( J:51128 )

• mutants that carry three mutant alleles in any combination show cleft face associated with failure to fuse the cartilages of the nasal septum

midline facial cleft ( J:51128 )

• mutant mice show a midline fusion defect that results in cleft face