Phenotypes Associated with This Genotype

Genotype
MGI:3050508

• Allelic Composition: Kif18a^gcd2/Kif18a^gcd2
• Genetic Background: involves: 129S1/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

decreased germ cell number ( J:86161 , J:111998 )

• occurs in both sexes (J:86161)

decreased oocyte number ( J:111998 )

♀

decreased male germ cell number ( J:111998 )

♂

reproductive system

reproductive system phenotype ( J:86161 )

N • phenotype about 65% penetrant

abnormal ovary morphology ( J:111998 )

♀ • at 20 to 22 weeks of age some homozygotes have normal appearing ovaries while others have tiny ovaries with few to no follicles and subfertile homozygotes have premature ovarian failure

abnormal ovarian follicle number ( J:111998 )

♀ • Background Sensitivity: sterile female adults have a dramatic reduction in the number of growing follicles while the phenotype is less severe in fertile adult females and on this segregating background the phenotype varies considerably between individuals

small ovary ( J:111998 )

♀

premature ovarian failure ( J:111998 )

♀ • subfertile homozygotes show premature ovarian failure with shortened reproductive life spans and small litters

abnormal gametogenesis ( J:86161 )

decreased germ cell number ( J:86161 , J:111998 )

• occurs in both sexes (J:86161)

decreased oocyte number ( J:111998 )

♀

decreased male germ cell number ( J:111998 )

♂

abnormal spermatogenesis ( J:86161 , J:111998 )

♂ • spermatogenesis occurs in some but not all seminiferous tubules (J:86161)

♂ • Background Sensitivity: in the segregating background there is great variety in the percentage of seminiferous tubules that are depleted of germ cells, with the sterile homozygotes having a higher percentage than the fertile homozygotes (J:111998)

infertility ( J:86161 )

• sterility in both sexes

endocrine/exocrine glands

abnormal ovary morphology ( J:111998 )

♀ • at 20 to 22 weeks of age some homozygotes have normal appearing ovaries while others have tiny ovaries with few to no follicles and subfertile homozygotes have premature ovarian failure

abnormal ovarian follicle number ( J:111998 )

♀ • Background Sensitivity: sterile female adults have a dramatic reduction in the number of growing follicles while the phenotype is less severe in fertile adult females and on this segregating background the phenotype varies considerably between individuals

small ovary ( J:111998 )

♀

premature ovarian failure ( J:111998 )

♀ • subfertile homozygotes show premature ovarian failure with shortened reproductive life spans and small litters

mortality/aging

premature ovarian failure ( J:111998 )

♀ • subfertile homozygotes show premature ovarian failure with shortened reproductive life spans and small litters