Phenotypes Associated with This Genotype

Genotype
MGI:3050407

• Allelic Composition: Hoxb1^tm5Mrc/Hoxb1^tm7Mrc; H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal reflex ( J:91364 )

• some mutants are unable to move their ears

abnormal blinking ( J:91364 )

• some mutants are unable to blink their eyes

abnormal vibrissae reflex ( J:91364 )

• some mutants are unable to move their whiskers

paralysis ( J:91364 )

• 35% of mutants show total facial paralysis and another 10% show partial facial paralysis

nervous system

decreased motor neuron number ( J:91364 )

• increased motor neuron loss is seen from E14.5 to E16.5 when motor neuron pruning normally occurs resulting a significant decrease in the average number of motor neurons in mutants compared to wild-type mice

abnormal facial nerve morphology ( J:91364 )

• loss of VII th cranial nerve branches is seen

• at E12.5 the average number of axonal branch points is decreased