Phenotypes Associated with This Genotype

Genotype
MGI:3050322

• Allelic Composition: Csk^tm1Tara/Csk^tm1Tara; Tg(Mx1-cre)1Cgn/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CB20 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

enlarged thymus ( J:49654 )

• thymus is large and contains both double positive and CD4+ cells

abnormal CD4-positive T cell differentiation ( J:49654 )

• a population of peripheral lymphocytes are produced which are CD4+ but with a 2-3 fold reduction in surface expression of CD4

absent CD8-positive, alpha-beta T cells ( J:49654 )

• CD8 single positive cells are absent

immune system

enlarged thymus ( J:49654 )

• thymus is large and contains both double positive and CD4+ cells

abnormal CD4-positive T cell differentiation ( J:49654 )

• a population of peripheral lymphocytes are produced which are CD4+ but with a 2-3 fold reduction in surface expression of CD4

absent CD8-positive, alpha-beta T cells ( J:49654 )

• CD8 single positive cells are absent

endocrine/exocrine glands

enlarged thymus ( J:49654 )

• thymus is large and contains both double positive and CD4+ cells