Phenotypes Associated with This Genotype

Genotype
MGI:3050227

• Allelic Composition: Hprt1^tm1Dhm/Hprt1^tm1Dhm
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

increased heart weight ( J:91410 )

♀ • the ratio of left ventricular weight to both tibia length and body weight is increased at 10 weeks of age

cardiac hypertrophy ( J:106044 )

♀ • exhibit mild hypertrophy

decreased cardiac muscle contractility ( J:106044 )

♀ • isolated cardiac myocytes exhibit a significant decrease in fractional cell shortening and smaller dL/dT values

decreased heart ventricle muscle contractility ( J:91410 )

♀ • the first derivatives of minimum and maximum left ventricular pressure, the fractional shortening, velocity of circumferential shortening corrected, and peak early-filling transmitral diastolic wave velocity are all decreased

♀ • treatment with isoproternol, a beta-adrenergic activator, reversed cardiac impairment in mutant hearts

abnormal cardiac muscle relaxation ( J:106044 )

♀ • isolated cardiac myocytes exhibit lower relaxation rates (-dL/dt) than wild-type

abnormal myocardial fiber physiology ( J:106044 )

♀ • under baseline conditions, left ventricular myocytes exhibit lower calcium transient amplitude and slower calcium transient decays

muscle

decreased cardiac muscle contractility ( J:106044 )

♀ • isolated cardiac myocytes exhibit a significant decrease in fractional cell shortening and smaller dL/dT values

decreased heart ventricle muscle contractility ( J:91410 )

♀ • the first derivatives of minimum and maximum left ventricular pressure, the fractional shortening, velocity of circumferential shortening corrected, and peak early-filling transmitral diastolic wave velocity are all decreased

♀ • treatment with isoproternol, a beta-adrenergic activator, reversed cardiac impairment in mutant hearts

abnormal cardiac muscle relaxation ( J:106044 )

♀ • isolated cardiac myocytes exhibit lower relaxation rates (-dL/dt) than wild-type

growth/size/body

increased heart weight ( J:91410 )

♀ • the ratio of left ventricular weight to both tibia length and body weight is increased at 10 weeks of age

cardiac hypertrophy ( J:106044 )

♀ • exhibit mild hypertrophy