Phenotypes Associated with This Genotype

Genotype
MGI:3047599

• Allelic Composition: Cd79a^tm4Cgn/Cd79a^tm4.1Cgn; Tg(Mx1-cre)1Cgn/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

arrested B cell differentiation ( J:91091 )

• 2 weeks after p(I)p(C) injections an almost complete block in B cell development is seen

decreased B cell number ( J:91091 )

• 2 weeks after p(I)p(C) injections two thirds of the B cells are lost from the spleen, blood, lymph nodes, liver, and lung

• mature follicular B cells are more affected than marginal zone B cells

absent immature B cells ( J:91091 )

• in the spleen almost all immature spleen cells are missing

decreased follicular B cell number ( J:91091 )

decreased marginal zone B cell number ( J:91091 )

immune system

arrested B cell differentiation ( J:91091 )

• 2 weeks after p(I)p(C) injections an almost complete block in B cell development is seen

decreased B cell number ( J:91091 )

• 2 weeks after p(I)p(C) injections two thirds of the B cells are lost from the spleen, blood, lymph nodes, liver, and lung

• mature follicular B cells are more affected than marginal zone B cells

absent immature B cells ( J:91091 )

• in the spleen almost all immature spleen cells are missing

decreased follicular B cell number ( J:91091 )

decreased marginal zone B cell number ( J:91091 )