Phenotypes Associated with This Genotype

Genotype
MGI:3047333

• Allelic Composition: Myb^tm1Cgn/Myb^tm1Cgn; Tg(Lck-cre)1Cwi/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

thymus hypoplasia ( J:91122 )

• thymus cellularity is reduced about 97%

decreased double-negative T cell number ( J:91122 )

• the absolute number of double negative cells is decreased about 40% however the proportion of double negative cells is increased to about 60% of total thymocytes

• about 90% of the double negative cells are CD44^-CD25⁺ DN3 cells

decreased double-positive T cell number ( J:91122 )

• the absolute number of double positive cells is greatly decreased

arrested T cell differentiation ( J:91122 )

• a block in thymocyte maturation at the DN3 stage or in the transition from DN3 to DN4 appears to occur

decreased CD4-positive, alpha-beta T cell number ( J:91122 )

• the absolute number of CD4 single positive cells is greatly decreased

decreased CD8-positive, alpha-beta T cell number ( J:91122 )

• the absolute number of CD8 single positive cells is greatly decreased

decreased gamma-delta T cell number ( J:91122 )

• the number of gamma delta TCR bearing thymocytes is decreased

immune system

thymus hypoplasia ( J:91122 )

• thymus cellularity is reduced about 97%

decreased double-negative T cell number ( J:91122 )

• the absolute number of double negative cells is decreased about 40% however the proportion of double negative cells is increased to about 60% of total thymocytes

• about 90% of the double negative cells are CD44^-CD25⁺ DN3 cells

decreased double-positive T cell number ( J:91122 )

• the absolute number of double positive cells is greatly decreased

arrested T cell differentiation ( J:91122 )

• a block in thymocyte maturation at the DN3 stage or in the transition from DN3 to DN4 appears to occur

decreased CD4-positive, alpha-beta T cell number ( J:91122 )

• the absolute number of CD4 single positive cells is greatly decreased

decreased CD8-positive, alpha-beta T cell number ( J:91122 )

• the absolute number of CD8 single positive cells is greatly decreased

decreased gamma-delta T cell number ( J:91122 )

• the number of gamma delta TCR bearing thymocytes is decreased

endocrine/exocrine glands

thymus hypoplasia ( J:91122 )

• thymus cellularity is reduced about 97%