Phenotypes Associated with This Genotype

Genotype
MGI:3047126

• Allelic Composition: Fanca^tm1Wong/Fanca^tm1Wong
• Genetic Background: involves: 129S6/SvEvTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

early reproductive senescence ( J:85108 )

• females exhibited premature reproductive senescence

reproductive system

decreased germ cell number ( J:85108 )

• observed in both 129S6/SvEvTac and C57BL/6 genetic backgrounds, however a more severe depletion was observed in the C57BL/6 background

increased male germ cell apoptosis ( J:85108 )

♂

seminiferous tubule degeneration ( J:85108 )

♂ • ~3% were severely degenerated, on a 129S6/SvEvTac genetic background

small testis ( J:85108 )

♂ • ~2-fold smaller than those of heterozygotes on a 129S6/SvEvTac coisogenic background

early reproductive senescence ( J:85108 )

• females exhibited premature reproductive senescence

abnormal spermatogenesis ( J:85108 )

♂ • a proportion of spermatocytes progressed through spermatogenesis to produce functional spermatozoa

abnormal male meiosis ( J:85108 )

♂ • elevated frequency of mispaired meiotic chromosomes

reduced female fertility ( J:85108 )

♀ • putatively due to a diminished population of primordial germ cells during migration into the genital ridge

♀ • male fertility was not impaired

endocrine/exocrine glands

seminiferous tubule degeneration ( J:85108 )

♂ • ~3% were severely degenerated, on a 129S6/SvEvTac genetic background

small testis ( J:85108 )

♂ • ~2-fold smaller than those of heterozygotes on a 129S6/SvEvTac coisogenic background

cellular

decreased germ cell number ( J:85108 )

• observed in both 129S6/SvEvTac and C57BL/6 genetic backgrounds, however a more severe depletion was observed in the C57BL/6 background

abnormal male meiosis ( J:85108 )

♂ • elevated frequency of mispaired meiotic chromosomes

increased male germ cell apoptosis ( J:85108 )

♂