Phenotypes Associated with This Genotype

Genotype
MGI:3046845

• Allelic Composition: Map3k5^tm1Hijo/Map3k5^tm1Hijo
• Genetic Background: B6.129S4-Map3k5^tm1Hijo

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:88195 )

N • cardiac morphology and function are not different from controls

decreased response of heart to induced stress ( J:88195 )

• 4 weeks after thoracic transverse aortic constriction fractional shortening, left ventricular end diastolic internal dimension, and lung weight are not significantly different from sham operated controls unlike in wild type mice

• decrease in the number of apoptotic cells detected at 1 and 4 weeks after thoracic transverse aortic constriction compared to wild-type controls

• however, 1 week after thoracic transverse aortic constriction heart weight is increased similar to what is seen in wild-type controls and the degree of fibrosis is similar in both mutant and wild-type mice

abnormal response to cardiac infarction ( J:88195 )

• following myocardial infarction increases in left ventricular end diastolic and end systolic internal dimensions are decreased compared to wild-type controls

• following myocardial infarction the decrease in fractional shortening and replacement fibrosis are less than that in wild-type controls

• decrease in the number of apoptotic cells detected at 1 and 4 weeks after induced infarction compared to wild-type controls

homeostasis/metabolism

decreased response of heart to induced stress ( J:88195 )

• 4 weeks after thoracic transverse aortic constriction fractional shortening, left ventricular end diastolic internal dimension, and lung weight are not significantly different from sham operated controls unlike in wild type mice

• decrease in the number of apoptotic cells detected at 1 and 4 weeks after thoracic transverse aortic constriction compared to wild-type controls

• however, 1 week after thoracic transverse aortic constriction heart weight is increased similar to what is seen in wild-type controls and the degree of fibrosis is similar in both mutant and wild-type mice

abnormal response to cardiac infarction ( J:88195 )

• following myocardial infarction increases in left ventricular end diastolic and end systolic internal dimensions are decreased compared to wild-type controls

• following myocardial infarction the decrease in fractional shortening and replacement fibrosis are less than that in wild-type controls

• decrease in the number of apoptotic cells detected at 1 and 4 weeks after induced infarction compared to wild-type controls

decreased physiological sensitivity to xenobiotic ( J:148044 )

• primary keratinocytes are more resistant to DMBA induced apoptosis compared to wild-type cells

• hyperplasia following TPA exposure is milder than in wild type controls