Phenotypes Associated with This Genotype

Genotype
MGI:3046844

• Allelic Composition: Map3k5^tm1Hijo/Map3k5^tm1Hijo
• Genetic Background: involves: 129S4/SvJae * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

decreased sensitivity to induced cell death ( J:88612 )

• decrease in the induction of apoptosis by TNF, H2O2 or other oxidative stressors in MEFs

mortality/aging

mortality/aging ( J:251158 )

N • following treatment with high doses of recombinant mouse TNF (mTNF), mice are only slightly protected from mTNF-induced lethality relative to wild-type controls

immune system

immune system phenotype ( J:251158 )

N • mice are not significantly protected from TNF (mTNF)-induced mortality and hypothermia