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Phenotypes Associated with This Genotype
Genotype
MGI:3046808
Allelic
Composition
Cdkn1atm2(HBx)Xya/Cdkn1atm2(HBx)Xya
Genetic
Background
either: (involves: 129S6/SvEvTac * C57BL/6) or (involves: 129S6/SvEvTac * Black Swiss)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn1atm2(HBx)Xya mutation (0 available); any Cdkn1a mutation (52 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• hepatocellular carcinoma (HCC) observed in 63.6% of male mice and in 42.9% of female mice after 18 months of age
• no metastases were detected
• HCC was multifocal with most mice exhibiting1 to 2 highly vascularized large tumors (0.5 to 2.5 cm) and many smaller tumors distributed throughout
• HCC compressing adjacent normal hepatocytes observed after 18 months of age and typically associated with fatty liver and inflammation

liver/biliary system
• observed in some mice
• hepatocellular carcinoma (HCC) observed in 63.6% of male mice and in 42.9% of female mice after 18 months of age
• no metastases were detected
• HCC was multifocal with most mice exhibiting1 to 2 highly vascularized large tumors (0.5 to 2.5 cm) and many smaller tumors distributed throughout
• HCC compressing adjacent normal hepatocytes observed after 18 months of age and typically associated with fatty liver and inflammation

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
hepatocellular carcinoma DOID:684 OMIM:114550
J:88078


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/12/2019
MGI 6.14
The Jackson Laboratory