Phenotypes Associated with This Genotype

Genotype
MGI:3046696

• Allelic Composition: Chek1^tm1Jmr/Chek1^tm1Jmr; Tg(Wap-cre)11738Mam/0
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal apoptosis ( J:91266 )

• about 10% - 12% is seen in the differentiating lobuloalveolar mammary epithelial cells compared to less than 1% in wild-type

decreased cell proliferation ( J:91266 )

• about 4% of cells in the mammary glands are proliferating at day 1 of lactation compared to 6.5% in wild-type

endocrine/exocrine glands

abnormal mammary gland growth during pregnancy ( J:91266 )

♀ • the number of lobuloalveolar mammary epithelial cells is reduced by 50% to 60% at day 1 of lactation in proportion to the number of cells expressing cre

abnormal lactation ( J:91266 )

♀ • females fail to nurse their young

reproductive system

abnormal mammary gland growth during pregnancy ( J:91266 )

♀ • the number of lobuloalveolar mammary epithelial cells is reduced by 50% to 60% at day 1 of lactation in proportion to the number of cells expressing cre

integument

abnormal mammary gland growth during pregnancy ( J:91266 )

♀ • the number of lobuloalveolar mammary epithelial cells is reduced by 50% to 60% at day 1 of lactation in proportion to the number of cells expressing cre

abnormal lactation ( J:91266 )

♀ • females fail to nurse their young