Phenotypes Associated with This Genotype

Genotype
MGI:3046421

• Allelic Composition: Lrp5^tm1Jfh/Lrp5^tm1Jfh; Lrp6^Gt(Ex187)Byg/Lrp6⁺
• Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:91055 )

• reduced viability with deaths occurring after birth

growth/size/body

decreased body size ( J:91055 )

• survivors are small as adults

decreased fetal size ( J:91055 )

• smaller size at E18.5

limbs/digits/tail

absent carpal bone ( J:91055 )

• missing carpal bones

oligodactyly ( J:91055 )

• loss of one or two digits on the forelimb

• only 1 or 2 digits present in the hind limb

absent fibula ( J:91055 )

absent metacarpal bones ( J:91055 )

• missing metacarpals

skeleton

absent carpal bone ( J:91055 )

• missing carpal bones

absent fibula ( J:91055 )

absent metacarpal bones ( J:91055 )

• missing metacarpals