Phenotypes for Lrp5 Lrp6 MGI:3046420 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Lrp5^tm1Jfh/Lrp5^tm1Jfh Lrp6^Gt(Ex187)Byg/Lrp6^Gt(Ex187)Byg
Genetic Background	involves: 129S5/SvEvBrd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrp5^tm1Jfh mutation (0 available); any Lrp5 mutation (81 available)
Lrp6^Gt(Ex187)Byg mutation (1 available); any Lrp6 mutation (95 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:91055 )

• development arrested prior to E10.5

• homozygotes die by E18.5

embryo

abnormal developmental patterning ( J:91055 )

• embryonic development normal until gastrulation

• visibly smaller and abnormal by E7.5

abnormal germ layer development ( J:91055 )

abnormal mesoderm development ( J:91055 )

absent endoderm ( J:91055 )

• absence of definitive endoderm

absent allantois ( J:91055 )

• no visible allantois

absent amnion ( J:91055 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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