Phenotypes Associated with This Genotype

Genotype
MGI:3046405

• Allelic Composition: Igha^tm1(Myc)Janz/Igha⁺; Tg(Igk-V21-Bax)1967Bvn/0
• Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

enlarged spleen ( J:90901 )

• 8 week old double transgenic exhibit splenomegaly with massive accumulation of plasma cells in extrafollicular areas

mortality/aging

decreased tumor-free survival time ( J:90901 )

• survival of double transgenics is markedly decreased as a result of malignant plasma cell tumors

neoplasm

increased leukemia incidence ( J:90901 )

• in some cases plasma cell leukemia is seen

increased plasmacytoma incidence ( J:90901 )

• malignant plasma cell tumors develop rapidly with a mean onset of 135 days, are fully penetrant, proliferate vigorously, occur in multiple tissues including the spleen, bone marrow, and lymph nodes, and may have monocentric or multicentric origins

• bone sections from double transgenic mice with less advanced tumors show multifocal lesions of aberrant pleomorphic plasma cells next to diminished of dissolved osseous trabeculae

• pathalogical fractures of the long bones are seen in some double transgenic mice

hematopoietic system

abnormal B cell apoptosis ( J:90901 )

• B cell apoptosis is increased compared to normal B cells but decreased compared to B cells from Igh-2^tm1Janz single transgenics

enlarged spleen ( J:90901 )

• 8 week old double transgenic exhibit splenomegaly with massive accumulation of plasma cells in extrafollicular areas

abnormal plasma cell morphology ( J:90901 )

• plasma cells participate in cell cycling unlike in normal mice

increased plasma cell number ( J:90901 )

• the bone marrow and spleen contain on average 42% and 34% plasma cells, respectively, compared to less than 2% in normal mice

increased IgG level ( J:90901 )

• elevation of IgG accompanied the increase in plasma cell numbers

increased IgM level ( J:90901 )

• elevation of IgM accompanied the increase in plasma cell numbers

immune system

abnormal B cell apoptosis ( J:90901 )

• B cell apoptosis is increased compared to normal B cells but decreased compared to B cells from Igh-2^tm1Janz single transgenics

enlarged spleen ( J:90901 )

• 8 week old double transgenic exhibit splenomegaly with massive accumulation of plasma cells in extrafollicular areas

abnormal plasma cell morphology ( J:90901 )

• plasma cells participate in cell cycling unlike in normal mice

increased plasma cell number ( J:90901 )

• the bone marrow and spleen contain on average 42% and 34% plasma cells, respectively, compared to less than 2% in normal mice

increased IgG level ( J:90901 )

• elevation of IgG accompanied the increase in plasma cell numbers

increased IgM level ( J:90901 )

• elevation of IgM accompanied the increase in plasma cell numbers

cellular

abnormal B cell apoptosis ( J:90901 )

• B cell apoptosis is increased compared to normal B cells but decreased compared to B cells from Igh-2^tm1Janz single transgenics