Phenotypes Associated with This Genotype

Genotype
MGI:3046404

• Allelic Composition: Tg(Igk-V21-Bax)1967Bvn/0
• Genetic Background: involves: FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

increased transitional stage B cell number ( J:89049 )

• the number of immature/transitional B cells is increased

abnormal plasma cell morphology ( J:89049 )

• plasma cell foci are seen in the kidney, bone marrow and other lymphoid tissues

increased immunoglobulin level ( J:89049 )

• in response to a T cell independent antigen transgenic mice produce 65% more specific Igs compared to littermate controls

increased IgA level ( J:89049 )

• IgA serum levels are increased

increased IgE level ( J:89049 )

• IgE serum levels are increased

increased IgG level ( J:89049 , J:90901 )

• a moderate elevation of 3 isotypes of IgG is seen (J:90901)

increased IgG1 level ( J:89049 )

• serum levels are increased

increased IgG2a level ( J:89049 )

• serum levels are increased

increased IgM level ( J:89049 )

• IgM serum levels are increased

homeostasis/metabolism

increased urine protein level ( J:89049 )

• some transgenic mice have detectable levels of Ig proteins in their urine

immune system

increased transitional stage B cell number ( J:89049 )

• the number of immature/transitional B cells is increased

abnormal plasma cell morphology ( J:89049 )

• plasma cell foci are seen in the kidney, bone marrow and other lymphoid tissues

increased immunoglobulin level ( J:89049 )

• in response to a T cell independent antigen transgenic mice produce 65% more specific Igs compared to littermate controls

increased IgA level ( J:89049 )

• IgA serum levels are increased

increased IgE level ( J:89049 )

• IgE serum levels are increased

increased IgG level ( J:89049 , J:90901 )

• a moderate elevation of 3 isotypes of IgG is seen (J:90901)

increased IgG1 level ( J:89049 )

• serum levels are increased

increased IgG2a level ( J:89049 )

• serum levels are increased

increased IgM level ( J:89049 )

• IgM serum levels are increased

renal/urinary system

increased urine protein level ( J:89049 )

• some transgenic mice have detectable levels of Ig proteins in their urine

abnormal kidney morphology ( J:89049 )

• multiple perivascular foci of lymphocytes are seen in the kidney

renal cast ( J:89049 )

• hyaline renal tubular casts presumably made of Ig proteins are found