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Phenotypes Associated with This Genotype
Genotype
MGI:3046320
Allelic
Composition
Myo15sh2/Myo15sh2
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myo15sh2 mutation (1 available); any Myo15 mutation (87 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hearing/vestibular/ear
• by 2.5 months of age type 1 hair cells of the crista ampullaris and utricular macula contain rod-shaped inclusions comprising actin filaments (J:6873)
• degeneration is evident in 2 week old mice (J:13046)
• occurs during the second week
• evident in 3 week old mutant mice
• the membrane is slow to thin to expected dimensions
• due to cochlear degeneration

behavior/neurological
• mutant mice show a tendency to run in circles

nervous system
• by 2.5 months of age type 1 hair cells of the crista ampullaris and utricular macula contain rod-shaped inclusions comprising actin filaments (J:6873)
• degeneration is evident in 2 week old mice (J:13046)
• degeneration is progressive from the time mutants are two weeks old


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/04/2018
MGI 6.13
The Jackson Laboratory