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Phenotypes Associated with This Genotype
Genotype
MGI:3046053
Allelic
Composition		 Htr3atm1Ckn/Htr3a+
Genetic
Background		 involves: 129S1/Sv * C57BL/6J * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Htr3atm1Ckn mutation (1 available); any Htr3a mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:90942 )
• heterozygous mutants die prematurely

renal/urinary system
abnormal urinary bladder physiology ( J:90942 )
• 6 week old heterozygous mice have weak voiding contractions which progresses to no voiding contractions in 8 week old heterozygotes
abnormal urination pattern ( J:90942 )
• heterozygous mice have an intermediate phenotype ranging from decreased void intervals to constant urine dribbling

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory