Phenotypes Associated with This Genotype

Genotype
MGI:3045884

• Allelic Composition: Ddx25^tm1Mld/Ddx25^tm1Mld
• Genetic Background: involves: 129S4/SvJae

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

increased male germ cell apoptosis ( J:89546 )

♂ • germ cell apoptosis is increased to greater than 30% per tubule in homozygous males

abnormal Leydig cell morphology ( J:89546 )

♂ • Leydig cells contain fewer lipid droplets and swollen mitochondria withou normal central cristae, however basal circulating testosterone levels are normal

decreased testis weight ( J:89546 )

♂ • testes weight is reduced by 25% in mutants

abnormal spermatogenesis ( J:89546 )

♂ • chromatid bodies are unusually condensed, much smaller, and lack the typical amorphous 'nuage' texture throughout spermatogenesis

arrest of spermatogenesis ( J:89546 )

♂ • spermatogenesis arrests after step 8 with round spermatids but no elongating cells seen

♂ • only degenerating spermatids are seen in the epididymis

male infertility ( J:89546 )

♂ • homozygous mutant males are sterile, but mutant females are fertile

endocrine/exocrine glands

abnormal Leydig cell morphology ( J:89546 )

♂ • Leydig cells contain fewer lipid droplets and swollen mitochondria withou normal central cristae, however basal circulating testosterone levels are normal

decreased testis weight ( J:89546 )

♂ • testes weight is reduced by 25% in mutants

cellular

increased male germ cell apoptosis ( J:89546 )

♂ • germ cell apoptosis is increased to greater than 30% per tubule in homozygous males