Analysis Tools
hematopoietic system
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• ability of macrophage to engulf apoptotic cells is impaired
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• splenomegaly develops with age
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• by 40 weeks spleen weight is 3X control
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• 2-3 times more lymphocytes in spleen but normal B cell to T cell ratio
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• enlarged follicular zones
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• enlarged white pulp
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immune system
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• ability of macrophage to engulf apoptotic cells is impaired
|
|
• splenomegaly develops with age
|
|
• by 40 weeks spleen weight is 3X control
|
|
• 2-3 times more lymphocytes in spleen but normal B cell to T cell ratio
|
|
• enlarged follicular zones
|
|
• enlarged white pulp
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endocrine/exocrine glands
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• reduced weights of later litters and death of 20-30% of pups
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integument
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• reduced weights of later litters and death of 20-30% of pups
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cellular
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• ability of macrophage to engulf apoptotic cells is impaired
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growth/size/body
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• splenomegaly develops with age
|
|
• by 40 weeks spleen weight is 3X control
|
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• 2-3 times more lymphocytes in spleen but normal B cell to T cell ratio
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