Phenotypes Associated with This Genotype

Genotype
MGI:3044767

• Allelic Composition: Spi1^tm1Kast/Spi1^tm1Kast
• Genetic Background: B6.129S2-Spi1^tm1Kast

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:90543 )

• homozygous mutants die within 1 day of birth

hematopoietic system

abnormal erythropoiesis ( J:90543 )

• from E11.5 - E12.5 the cellularity of homozygous mutant fetal livers is about 50% that of wild-type this difference is gone by E13.5

• in culture erythroid progenitors from homozygous mutants do not increase in number and produce disproportionately more mature erythroid cells compared to cells from wild-type mice

failure of myelopoiesis ( J:90543 )

• myeloid lineage cells are absent from the fetal liver of homozygous mutants

abnormal fetal derived definitive erythrocyte cell number ( J:90543 )

• at E12.5 fetal livers from homozygous mutants contain fewer mature erythroid cells

• by E15.5 however the number of mature erythroid cells is significantly higher in homozygous mutant fetal livers

absent B cells ( J:90543 )

• B-lineage cells are absent from the fetal liver of homozygous mutants

immune system

failure of myelopoiesis ( J:90543 )

• myeloid lineage cells are absent from the fetal liver of homozygous mutants

absent B cells ( J:90543 )

• B-lineage cells are absent from the fetal liver of homozygous mutants