Phenotypes Associated with This Genotype

Genotype
MGI:3044725

• Allelic Composition: Abcb1a^mds/Abcb1a^mds
• Genetic Background: involves: CF-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Abcb1a^mds/Abcb1a^mds mice exhibit selective neurologic ivermectin toxicity in the hippocampal CA3 field that is not seen in wild-type mice

mortality/aging

premature death ( J:64725 )

• response to ivermectin toxicity

homeostasis/metabolism

increased physiological sensitivity to xenobiotic ( J:64725 , J:40292 )

• increased sensitivity to ivermectin producing neurotoxic responses when a sublethal dose 2mg/kg body weight is administered IP (J:64725)

• histopathological data show the hippocampal CA3 region is highly susceptible (J:64725)

• increased sensitivity to neurotoxicity induced by avermectins (abamectin and ivermectin) (J:40292)

behavior/neurological

tremors ( J:64725 )

• response to ivermectin toxicity

catalepsy ( J:64725 )

• response to ivermectin toxicity

hematopoietic system

increased eosinophil cell number ( J:64725 )

• acidophilic cytoplasmic staining shows an abundance of eosinophils in the hippocampus CA3 layer

immune system

increased eosinophil cell number ( J:64725 )

• acidophilic cytoplasmic staining shows an abundance of eosinophils in the hippocampus CA3 layer

nervous system

abnormal hippocampus CA3 region morphology ( J:64725 )

hippocampal neuron degeneration ( J:64725 )

• noted in histological analysis of the CA3 region