Phenotypes Associated with This Genotype

Genotype
MGI:3044594

• Allelic Composition: Edn1^tm1Ywa/Edn1^tm1Ywa; Tg(Myh6-cre)2182Mds/0
• Genetic Background: involves: 129S6/SvEvTac * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

decreased response of heart to induced stress ( J:90390 , J:96386 )

• mice are resistant to hyperthyroid cardiac hypertrophy, showing a 57% reduction in cardiac hypertrophy in response to tri-iodothyronine (T3) relative to control mice (J:90390)

• left ventricular mass is increased by 3% in response to T3, compared to a 27% increase observed in similarly treated control mice (J:90390)

• the magnitude of Trypanosoma cruzi infection-associated cardiomyopathy is significantly less than in controls (J:96386)

homeostasis/metabolism

decreased response of heart to induced stress ( J:90390 , J:96386 )

• mice are resistant to hyperthyroid cardiac hypertrophy, showing a 57% reduction in cardiac hypertrophy in response to tri-iodothyronine (T3) relative to control mice (J:90390)

• left ventricular mass is increased by 3% in response to T3, compared to a 27% increase observed in similarly treated control mice (J:90390)

• the magnitude of Trypanosoma cruzi infection-associated cardiomyopathy is significantly less than in controls (J:96386)