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Phenotypes Associated with This Genotype
Genotype
MGI:3044360
Allelic
Composition		 Hsf1tm1Anak/Hsf1tm1Anak
Tg(ACTB-HSF1)1Anak/?
Genetic
Background		 involves: C57BL/6 * CBA * ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hsf1tm1Anak mutation (1 available); any Hsf1 mutation (23 available)
Tg(ACTB-HSF1)1Anak mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
abnormal seminiferous tubule morphology ( J:89846 )
• diameter of seminiferous tubules is larger than in mice expressing endogenous Hsf1 as well as the transgene
decreased testis weight ( J:89846 )
• testis weight is low compared to normal controls but greater than in mice expressing endogenous Hsf1 as well as the transgene

reproductive system
reproductive system phenotype ( J:89846 )
N
• spermatogenesis is normal
abnormal seminiferous tubule morphology ( J:89846 )
• diameter of seminiferous tubules is larger than in mice expressing endogenous Hsf1 as well as the transgene
decreased testis weight ( J:89846 )
• testis weight is low compared to normal controls but greater than in mice expressing endogenous Hsf1 as well as the transgene

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory