Phenotypes Associated with This Genotype

Genotype
MGI:3044192

• Allelic Composition: Cd9^tm1Kudo/Cd9^tm1Kudo
• Genetic Background: involves: 129X1/SvJ * C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

reproductive system phenotype ( J:60753 )

N • male fertility remained unaffected

female infertility ( J:60753 )

♀ • only two newborn pups were obtained from 1 of 16 matings using mutant females

impaired fertilization ( J:60753 )

• sperm-egg binding was normal, but sperm-egg fusion was almost entirely inhibited in mutant eggs

• intracellular Ca2+ oscillations, which signal fertilization, were absent in almost all mutant eggs: no Ca2+ oscillation occurred within 90 min after sperm attachment

• in rare instances, the first Ca2+ transient occurred more than 30 min after sperm attachment (versus within 30 min in most wild-type eggs)