Phenotypes Associated with This Genotype

Genotype
MGI:3044044

• Allelic Composition: Ppp3r1^tm2Grc/Ppp3r1^tm2.1Grc; Tg(Lck-cre)1Cwi/0
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal positive T cell selection ( J:89771 )

• double positive (DP) thymocytes cannot progress to the single positive (SP)

• DP thymocytes show defects in induction of TCRb, CD69, and CD5 which are markers of positive selection

• negative selection was unaffected

abnormal splenic cell ratio ( J:89771 )

• decreased numbers of T lymphocytes compared to controls

immune system

abnormal positive T cell selection ( J:89771 )

• double positive (DP) thymocytes cannot progress to the single positive (SP)

• DP thymocytes show defects in induction of TCRb, CD69, and CD5 which are markers of positive selection

• negative selection was unaffected

abnormal splenic cell ratio ( J:89771 )

• decreased numbers of T lymphocytes compared to controls

abnormal lymph node cell ratio ( J:89771 )

• decreased numbers of T lymphocytes compared to controls

homeostasis/metabolism

abnormal enzyme/coenzyme activity ( J:89771 )

• ERK activation is defective in Ppp3r1-deficient animals