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Phenotypes Associated with This Genotype
Genotype
MGI:3043596
Allelic
Composition
Ercc5tm2Shm/Ercc5tm2Shm
Genetic
Background
involves: 129S2/SvPas * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ercc5tm2Shm mutation (0 available); any Ercc5 mutation (30 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
N
• homozygous mice have a normal lifespan

growth/size/body
N
• homozygous mice do not display any growth abnormalities

homeostasis/metabolism
• cells from homozygous mutants are more sensitive to UV light than cells from wild-type mice but not as sensitive as cells from Ercc5tm1Shm
• UV induced DNA lesions are partially removed in homozygous mutant cell

integument
• cells from homozygous mutants are more sensitive to UV light than cells from wild-type mice but not as sensitive as cells from Ercc5tm1Shm
• UV induced DNA lesions are partially removed in homozygous mutant cell

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
xeroderma pigmentosum group G DOID:0110849 OMIM:278780
J:89911


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/18/2017
MGI 6.08
The Jackson Laboratory