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Phenotypes Associated with This Genotype
Genotype
MGI:3043575
Allelic
Composition		 Htr1atm1Tct/Htr1a+
Genetic
Background		 involves: 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Htr1atm1Tct mutation (0 available); any Htr1a mutation (26 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
behavioral despair ( J:51565 )
• compared with homozygotes, heterozygotes displayed intermediate antidepressant-like responses in the tail-suspension test
increased anxiety-related response ( J:51565 )
• compared with homozygotes, heterozygotes displayed intermediate anxiety levels in the open-field, elevated-zero maze, and novel-object avoidance assays

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory